Pheochromocytoma pc12 cells
WebAug 5, 2024 · In rat pheochromocytoma PC12 cells, Wnt3a treatment enhanced cell proliferation and suppressed mRNA expression of tyrosine hydroxylase (TH), the rate-limiting enzyme of catecholamine biosynthesis, and dopamine secretion. We identified the expression of sclerostin in PC12 cells, which is known as an osteocyte-derived negative … WebThe pheochromocytoma (PC12) cell line is commonly used in in vitro studies to examine neuronal differentiation and neurotoxicity implicated in neurodegenerative disease [ 1, 2 ]. PC12 cells are noradrenergic clonal cells originating from Rattus norvegicus transplantable pheochromocytoma [ 1 ].
Pheochromocytoma pc12 cells
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WebJan 1, 1982 · PC12 cells propagated in vivo or in culture without nerve-growth factor are readily classifiable as pheochromocytomas by current morphological and chemical … WebThe PC12 clone, developed from a pheochromocytoma tumor of the rat adrenal medulla, has become a premiere model for the study of neuronal differentiation.
WebApr 14, 2024 · The PC12 cell line is one of the most commonly used in neuroscience research, including studies on neurotoxicity, neuroprotection, neurosecretion, neuroinflammation, and synaptogenesis. Two types of this line are available in the ATCC collection: traditional PC12 cells grown in suspension and well-attached adherent … The PC12 cell line has been used to get more information about diseases of the brain. It has been used in research of hypoxia, where acute hypoxia induces exocytosis and prolonged hypoxia can induce excessive exocytosis. PC12 cells were used to find which prion protein fragments caused neuronal dysfunction. In … See more PC12 is a cell line derived from a pheochromocytoma of the rat adrenal medulla, that have an embryonic origin from the neural crest that has a mixture of neuroblastic cells and eosinophilic cells. See more This cell line was first cultured by Greene and Tischler in 1976. It was developed in parallel to the adrenal chromaffin cell model because of its extreme versatility for pharmacological manipulation, ease of culture, and the large amount of information on their … See more Research has shown differences in vesicle size and quantal size depending on treatment with certain drugs. • L-DOPA has shown increase in average quantal size when treated for only 40–90 minutes. • Treatment with amphetamine or reserpine causes … See more • Wikipedia articles containing the term "PC12 cells" [1] • Ras function was partially elucidated using PC12 cell line [2], from section in Cancer Medicine textbook See more Their embryological origin with neuroblastic cells means they can easily differentiate into neuron-like cells even though they are not considered adult neurons. Neuron-like means they share properties similar to neurons, in this case it is referring to releasing … See more PC12 cells have been researched to evaluate the potential for pharmaceutical alternation of dopamine metabolites such as DOPAL, an autotoxin implicated in the pathology of See more • Cell culture • Adrenal medulla • Cellular differentiation • Pheochromocytoma See more
WebDec 8, 2024 · PC12 cells are a rat adrenal pheochromocytoma cell line, a monoclonal cell line transplanted from rat adrenal medulloblastoma by Greene and Tischler in 1976 ( Greene and Tischler, 1976 ). As a catecholamine cells, PC12 cells can synthesize, store and release appropriate amounts of catecholamines (mainly dopamine and norepinephrine). WebMay 1, 2007 · In rat pheochromocytoma (PC-12) cells the dopamine D 2 receptor agonists apomorphine (APO) and n-propylnorapomorphine (NPA) produced a concentration …
WebIn this report, we describe the transfection of the nerve growth factor (NGF)-responsive pheochromocytoma cell line PC12 with the human GAP-43 cDNA under the control of the …
WebDec 16, 2011 · (PDF) Phospholipase A2 and Signaling Pathways in Pheochromocytoma PC12 Cells Phospholipase A2 and Signaling Pathways in Pheochromocytoma PC12 Cells Authors: Alexey Osipov Yuri N Utkin Russian... maggie clipartWebApr 6, 2024 · Rat pheochromocytoma (PC12) cells are a popular model to study neuronal differentiation, survival and apoptosis. They are round-shaped and proliferate readily under normal culturing conditions.... maggie cloude death notice baltimore mdWebJun 12, 2024 · Cells from the pheochromocytoma cell line PC12 were purchased from the American Type Culture Collection (Manassas, VA, USA) and were cultured for 2 days to ~85% confluencu in the DMEM supplemented with 10% (for growth) or 2% (for maintenance) FBS and 100 U/ml penicillin/streptomycin (CSPC Pharmaceutical Group, Ltd., … maggie cliftoncounty vaccination dataWebThe rat pheochromocytoma PC12 cell line can easily be manipulated to study neuronal differentiation and apoptosis. When cells are cultured with serum, addition of PACAP inhibits cell proliferation and induces neurite outgrowth. When cells are cultured in serum-free medium, PACAP promotes PC12 survival and neuritogenesis. ... county rd 103 carbondale coWebApr 11, 2024 · Cocaine. and amphetamine-regulated transcript peptide (CARTp) is an anorexigenic neuropeptide whose receptor is undisclosed. Previously, we reported the specific binding of CART(61–102) to pheochromocytoma PC12 cells, where CART(61–102) affinity and the number of binding sites per cell corresponded to ligand-receptor binding. county\u0027s capital improvement programWebAbstract. Rat pheochromocytoma PC12 cells have been widely used to investigate the neurotrophic activities of pituitary adenylate cyclase-activating polypeptide (PACAP). In particular, PACAP has been shown to promote differentiation and to inhibit apoptosis of PC12 cells. In order to identify the mechanisms mediating these effects, we sought ... county of san diego accela citizen access