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Web18 jun. 2024 · Duloxetine must not be used in patients with severe renal impairment (creatinine clearance <30 ml/min; see section 4.3). Paediatric population Duloxetine should not be used in children and adolescents under the age of 18 years for the treatment of major depressive disorder because of safety and efficacy concerns (see sections 4.4, 4.8 and … Web7 jun. 2024 · There is a large degree of interindividual variation reported in the clearance of duloxetine with values ranging from 57-114 L/h. Steady state concentrations have still been shown to be dose proportional with a doubling of dose from 30 to 60 mg and from 60 to 120 mg producing 2.3 and 2.6 times the Css respectively. Web29 nov. 2024 · Cymbalta (duloxetine) Effexor (venlafaxine) Pristiq (desvenlafaxine) Tricyclic Antidepressants (TCAs) TCAs are better for diarrhea-predominant IBS (IBS-D). These drugs slow down gut motility, which helps reduce diarrhea and alleviate pain. Some commonly prescribed TCAs are: Elavil (amitriptyline) Tofranil (imipramine) Norpramin (desipramine) iowa lottery winner claim form