Circrna protein interaction
WebCircRNAs may also interact with regulatory RBPs, including through their activity as protein sponges, decoys, scaffolds, and recruiters, and further affect the fate of their target …
Circrna protein interaction
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WebAug 10, 2024 · RNA pull-down and immunoprecipitation (RIP) assays were used to analyze the interaction between circRNA_102231 and IRTKS. CircRNA_102231 expression was significantly upregulated in GC tissue and plasma samples, which can be used as a biomarker for GC diagnosis and prognosis. WebCircularRNA (circRNA) is an emerging ncRNA with a highly stable closed-loop structure formed by reverse splicing at the 3′ and 5′ ends, which is formed mainly by exons, introns or intergenic regions [ 9, 10, 11 ]. MicroRNA (miRNA) is a class of endogenous non-coding RNA, around 21–25 nucleotides in length [ 12 ].
WebApr 13, 2024 · Recent studies have shown that circRNA molecules act as miRNA sponges in cells, thereby relieving the inhibition effect of miRNA on its target genes and increasing the expression level of target genes. This mechanism of action is called the competitive endogenous RNA (ceRNA) mechanism [ 10, 11, 12 ]. WebOct 7, 2024 · Finally, we describe the best-performing methods to predict interactions between proteins and specific classes of RNA molecules, such as circular RNAs (circRNAs) and long non-coding RNAs (lncRNAs), and methods to predict RNA-RNA or RNA-RBP interactions independently of the RNA type.
WebMar 23, 2024 · CircRNA-Protein Interactions in Muscle Development and Diseases Circular RNA (circRNA) is a kind of novel endogenous noncoding RNA formed through … WebMar 23, 2024 · CircRNA–Protein Interactions Regulating Muscle Development and Diseases In recent years, more and more studies have found that noncoding RNA …
WebStarting from the evidence that some miRNAs and circRNAs are involved in the regulatory networks of the tumor suppressor protein p53, the possibility that a functional inhibition of p53 could arise from a direct interaction between p53 and oncogenic miRNAs or …
WebApr 12, 2024 · So far, most reported circRNAs promote the development and progression of RCC through circRNA-microRNA-mRNA interaction networks [ 17 ]. The ability of circRNAs to act as scaffolds to... northern ozaukee elementaryWebMar 23, 2024 · In this review, we systematically characterize the possible molecular mechanism of circRNA–protein interactions, summarize the latest research on … northern ozaukee skywardWebApr 13, 2024 · what: We screened the DE mRNAs, circRNAs, and miRNAs in the kidneys of TX-J mice with WD, and constructed the circRNA-miRNA-mRNA network. how: QRT-PCR results were analyzed using GraphPad software via the Student`s t-test with p and amplt 0.05 accepted as statistically significant. The results showed that all chromosomes … northern p2pWebDec 14, 2024 · CircRNAs exert biological functions by acting as transcriptional regulators, microRNA (miR) sponges and protein templates. Moreover, emerging evidence has … northern owl yellowWebCircular RNAs (circRNAs) are a recently discovered class of RNAs derived from protein-coding genes that have important biological and pathological roles. They are formed through backsplicing during co-transcriptional alternative splicing; however, the unified mechanism that accounts for backsplicing decisions remains unclear. northern pacific 4-6-2 locomotiveWebFeb 15, 2024 · CircRNAs could bind to the different proteins to form specific circRNA-protein complexes (circRNPs) that subsequently regulates the action of associated protein, the subcellular localization of proteins as well as … northern pacerWebJan 7, 2024 · The significant function of circRNAs in cancer was recognized in recent work, so a well-organized resource is required for characterizing the interactions between … northern oysters